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Impacts of Food Hypersensitivities on Quality of Life in the UK and Willingness to Pay (WTP) to remove those impacts

Appendix K. Sample Descriptives – Condition-Specific Measures of Quality of Life - Adults and Children

How the impact of living with a food hypersensitivity, and the gain to be valued if it was removed was captured.

Diweddarwyd ddiwethaf: 15 December 2022
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Diweddarwyd ddiwethaf: 15 December 2022
Gweld yr holl ddiweddariadau

The impact of living with a food hypersensitivity, and hence the gain to be valued if it was removed, was captured using three approaches: 
•    Baseline and contingent EQ-5D;
•    Baseline and contingent Visual Analogue Scale (VAS);
•    Condition-specific measures (FAQLQ, FIQLQ, or CDQ) for children.

This section of the report covers condition-specific measures (FAQLQ, FIQLQ, and CDQ).

Adult Results: FAQLQ, FIQLQ, and CDQ 

Food Allergy: FAQLQ

The FAQLQ is scored between 1 and 7 - the mean score in the adult sample was 4.8 and the median score was 5.1.

Table 1. Summary statistics: FAQLQ index

- Mean Std. Dev N min p25 Median p75 max
FAQ total 4.76 1.49 385 1.14 3.66 5.1 6 7

The adult distribution of FAQLQ scores is shown in Figure 1

Figure 1 Distribution of FAQLQ scores (adult allergy)

Annex K Figure 1

Women’s FAQLQ scores were on average than men’s, mean their allergy impacts were greater than those for men.

Table 2. Summary statistics:  FAQLQ Index by sex

Sex mean sd N min p25 Median p75 max
Female 4.96 1.44 226 1.31 3.93 5.38 6.1 7
Male 4.18 1.47 85 1.21 3.17 4.24 5.28 7

The FAQLQ scores were similar across age groups except for those over 65 whose scores were lower than the younger age groups.

Table 3 Summary statistics:  FAQLQ Index by age

Age mean sd N min p25 Median p75 max
Below 35 years old 4.9 1.3 104 1.79 3.91 5.22 5.97 7
35-54 years old 4.87 1.59 140 1.21 3.62 5.38 6.12 7
 55-64 years old 1.9 1.41 71 1.76 3.97 5.07 6.21 6.97
 65 years old and above 4.23 1.56 69 1.14 2.83 4.59 5.45 7

Coeliac Disease: CDQ

The 20 items of the CDQ are scored 1 to 5 meaning that the instrument can takes values between 20 and 100. The mean CDQ score in the sample was 48 and the median score was 47.

Table 4. Summary statistics: CDQ index

- Mean Std. Dev. N min p25 Median p75 max
CDQ total 48.35 16.91 601 20 34 47 61 95

The distribution of CDQ scores is shown in Figure 2.

Figure 2 Distribution of CDQ scores (adult coeliacs)

Annex K Figure 2

Male and female CDQ scores are very similar

Table 5. Summary statistics: CDQ Index by sex 

Sex mean sd N min p25 Median p75 max
Female 50.263 16.648 293 21 37 48 63 89
Male 49.355 17.139 76 20 35 48 61.5 88

The CDQ scores declined as age increases- older people typically report less severe impacts of coeliac disease on their life. Epidemiological studies support that coeliac disease can develop at any age in the lifecourse [Dube et al (2005)]. The non-specific symptoms and/or asymptomatic nature of coeliac disease mean it is often diagnosed later (~ 40 to 50 years of age) in life but as people age they may adjust to living with their diagnosis such that it impacts less on day-to-day activities and wellbeing (see Table 6) [Paez et al (2017); Zipser et al (2003); Ludvigsson et al (2014)]. 

Table 6. Summary statistics:    CDQ Index by age

Age mean sd N min p25 Median p75 max
Below 35 years old 57 15.42 79 27 44 58 67 89
35-54 years old 51.31 17.36 164 21 37 51 65 95
 55-64 years old 46.65 15.99 177 20 34 44 55 90
65 years old and above 43.42 16.06 180 20 30 41 54 88

Food Intolerance: FIQLQ

The FIQLQ is scored between 1 and 7 - the mean score in the adult sample was 4.5 and the median score was 4.7.

Table 7 Summary statistics: FIQLQ Index

- Mean Std. Dev. N min p25 Median p75 max
FIQ total 4.49 1.53 440 1.06 3.28 4.67 5.72 7

Figure 3 Distribution of FIQLQ scores (adult intolerance)

Annex K Figure 3

Women’s FIQLQ scores were on average higher than men’s, mean their food intolerance impacts were greater than those for men.

Table 8. Summary statistics:   FIQLQ Index by sex 

Sex mean sd N min p25 Median p75 max
Female 4.46 1.46 276 1.17 3.39 4.56 5.61 7
Male 4.18 1.56 92 1.06 2.97 4.33 5.47

6.72

The scores were similar across age groups except for those over 65 whose scores were lower than the younger age groups.

The FIQLQ scores increased as age increases - older people typically report more severe impacts of their food intolerance.

Table 9. Summary statistics:  FIQLQ Index by age 

Age mean sd N min p25 Median p75 max
Below 35 years old 4.27 1.49 62 1.56 3.06 4.17 5.5 6.94
35-54 years old 4.46 1.5 158 1.06 3.22 4.72 5.61 7
55-64 years old 4.51 1.49 124 1.17 3.39 4.69 5.67 7
65 years old and above 4.66 1.68 93 1.06 3.56 5.11 6.11 7

Child Results: 

Child Food Allergy: FAQLQ-PF and FAQLQ-PFT

The Food Allergy Quality of Life Questionnaire-Parent Form (FAQLQ-PF) was used for children aged 0-12 and the Food Allergy Quality of Life Questionnaire – Parent Form – for Adolescents (FAQLQ-PFT) was used for adolescents aged 13-17.  These forms were completed by parents.

Both instruments, like the adult FAQLQ, comprises multiple items scored 1 to 7. The scores are averaged across the items to generate an individual-level score between 1 and 7.

The child/youth mean and median FAQLQ scores was 4.1.

Table 10. Summary statistics: child/youth FAQLQ index

- Mean Std. Dev. N min p25 Median p75 max
FAQ 4.1 1.41 496 1 3.04 4.07 5.15 7

Figure 4. Distribution of FAQLQ scores (child, allergy)

Annex K Figure 4

Child Food Intolerance: FIQLQ-PF

The Food Intolerance Quality of Life Questionnaire- Parent Form (FIQLQ-PF) was used for all children (although the questions used differ according to the age of the child).  These assessments were completed by parents. The mean FIQLQ-PF score was 3.6 and the distribution of scores is shown in Figure 5.

Table 11. Summary statistics: FIQLQ-PF Index

- Mean Std. Dev. N min p25 Median p75 max
FIQ 3.63 1.4 147 1.16 2.55 3.5 4.68 6.8

Figure 5. Distribution of FIQLQ scores (child, intolerance)

Annex K Figure 5

Child Coeliac Disease: Celiac Disease DUX (CCDUX)
The Coeliac Disease DUX (CCDUX) is a validated HRQOL proxy questionnaire that parents complete about their children's condition. Responses are rated on a five-picture facial expression Likert scale on which a higher score indicates a worse quality of life. 

Table 12. Summary statistics: CCDUX index

- Mean Std. Dev. N min p25 Median p75 max
CCDUX 41.66 9.18 73 15 36 42 48 60

Figure 6. Distribution of CCDUX scores (child, coeliac)

Annex K Figure 6